Protosappanin B ( (-)-Protosappanin B )

产品货号. M17754 CAS No. 102036-29-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Protosappanin B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Protosappanin B 是从苏木中提取的多酚类物质，具有抗肿瘤作用。在人膀胱癌细胞中，能够使细胞周期 G1 期停滞，诱导细胞凋亡。
产品描述

Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.
体外实验

Protosappanin B (12.5, 25, 50, 100, 200 μg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 μg/mL, 26.73 μg/mL, and 76.53 μg/mL for SW-480, HCT-116, and BTT cells, respectively. Cell Viability Assay Cell Line:CT-116, SW-480, and BTT Cells Concentration:12.5, 25, 50, 100, 200 μg/mL Incubation Time:48 hours Result:Dose-dependently inhibited tumor cells after 48 hours of treatment.
体内实验

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同义词

(-)-Protosappanin B
通路

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靶点

Other Targets
受体

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研究领域

Others-Field
适应症

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